Frown repeatedly and engage the muscles that have been injected this has been shown to hasten the effect and increase the duration of action. It will generally take 2-3 weeks for full effect to be reached. Do not rub or touch the treated area for 3-4 hours. Do not lie down for at least 3-4 hours and avoid make up for this period of time too. – if applying make up please use a light dabbing motion instead of rubbing and spreading. Avoid exercise for 3-4 hours after treatment.